Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.62 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.59 |
| ▸ | BRAF | P15056 | 6/20 | 0.55 |
| ▸ | RAF1 | P04049 | 3/20 | 0.55 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.45 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4372559 | 0.84 | KDR (0.85) | KDRPDE10ABRAFRAF1CSNK1A1 | |
| SCHEMBL4359495 | 0.84 | KDR (0.58) | KDRBRAFRAF1CSNK1A1GSK3B | |
| SCHEMBL4360543 | 0.83 | KDR (0.57) | KDRPDE10ABRAFRAF1CSNK1A1 | |
| SCHEMBL4360523 | 0.82 | KDR (0.56) | KDRBRAFRAF1CSNK1A1GSK3B | |
| SCHEMBL17522957 | 0.80 | RAF1 (0.75) | KDRBRAFRAF1CSNK1A1GSK3B | |
| SCHEMBL1998478 | 0.79 | KDR (0.63) | KDRPDE10ABRAFRAF1MEN1 | |
| SCHEMBL4541465 | 0.78 | KDR (0.52) | KDRBRAFRAF1 | |
| SCHEMBL4363514 | 0.78 | RAF1 (0.88) | KDRBRAFRAF1CSNK1A1GSK3B | |
| SCHEMBL14601467 | 0.78 | RAF1 (0.66) | KDRBRAFRAF1 | |
| SCHEMBL2490261 | 0.75 | PDE10A (1.00) | KDRPDE10ACSNK1A1CSNK1DMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638954-A1 | FUSED AZOLES SUCH AS 2,5-DISUBSTITUTED BENZIMIDAZOLES, BENZOXAZOLES AND BENZOTHIAZOLES AS KINASE INHIBITORS | AMGEN INC. (US) | 2006-03-29 | — | — | EP | disclosed |
| WO-2004085425-A1 | FUSED AZOLES SUCH AS 2,5-DISUBSTITUTED BENZIMIDAZOLES, BENZOXAZOLES AND BENZOTHIAZOLES AS KINASE INHIBITORS | AMGEN INC (US) | 2004-10-07 | — | — | WO | disclosed |