Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 2/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 6/20 | 0.38 |
| ▸ | JAK2 | O60674 | 11/20 | 0.37 |
| ▸ | JAK1 | P23458 | 11/20 | 0.37 |
| ▸ | PTK2B | Q14289 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL578840 | 0.87 | PTK2 (0.52) | PTK2PTK2B | |
| SCHEMBL578715 | 0.87 | PTK2 (0.52) | PTK2PTK2B | |
| SCHEMBL578706 | 0.84 | MAPK9 (0.47) | MAPK9MAPK10PTK2JAK2JAK1 | |
| SCHEMBL578960 | 0.82 | MAPK9 (0.41) | MAPK9MAPK10PTK2JAK2JAK1 | |
| SCHEMBL14377725 | 0.81 | PTK2 (0.53) | PTK2PTK2B | |
| SCHEMBL579387 | 0.80 | MAPK9 (0.44) | MAPK9MAPK10PTK2JAK2JAK1 | |
| SCHEMBL578957 | 0.76 | PTK2 (0.59) | PTK2PTK2B | |
| SCHEMBL2322578 | 0.75 | PTK2 (0.58) | PTK2PTK2B | |
| SCHEMBL2320184 | 0.75 | PTK2 (0.58) | PTK2PTK2B | |
| SCHEMBL13808185 | 0.75 | PTK2 (0.56) | PTK2PTK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027107-B1 | 2, 4 -DIAMINO PYRIMIDINES AS CELL CYCLE KINASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2012-02-15 | — | — | EP | disclosed |