Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 6/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3604424 | 0.82 | PDE4D (0.45) | ITGB1ITGA4PDE4APDE4DPDE4B | |
| SCHEMBL3614945 | 0.81 | PDE4A (0.46) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL3606680 | 0.79 | MEN1 (0.54) | ITGB1ITGA4PDE4AEPHX2PDE4D | |
| SCHEMBL3601836 | 0.72 | DRD4 (0.44) | ITGB1ITGA4PDE4APDE4DPDE4B | |
| SCHEMBL13343012 | 0.71 | PDE4A (0.47) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL3612489 | 0.71 | PDE4B (0.41) | ITGB1ITGA4PDE4APDE4DPDE4B | |
| SCHEMBL3604334 | 0.70 | PDE4D (0.52) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL3611286 | 0.69 | MEN1 (0.52) | ITGB1ITGA4PDE4AEPHX2PDE4D | |
| SCHEMBL3603255 | 0.69 | PSEN1 (0.41) | ITGB1ITGA4PDE4APDE4DPDE4B | |
| SCHEMBL3602989 | 0.69 | PDE4A (0.44) | ITGB1ITGA4PDE4APDE4DPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1631568-A1 | PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceuticals Corporation (US) | 2006-03-08 | — | — | EP | claimed |
| WO-2004094411-A1 | PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2004-11-04 | — | — | WO | claimed |