Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.68 |
| ▸ | LCK | P06239 | 1/20 | 0.60 |
| ▸ | CSF1R | P07333 | 1/20 | 0.60 |
| ▸ | IGF1R | P08069 | 1/20 | 0.60 |
| ▸ | MET | P08581 | 1/20 | 0.60 |
| ▸ | KIT | P10721 | 1/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.60 |
| ▸ | SRC | P12931 | 1/20 | 0.60 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.60 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.60 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.60 |
| ▸ | TEK | Q02763 | 1/20 | 0.60 |
| ▸ | RAF1 | P04049 | 9/20 | 0.52 |
| ▸ | BRAF | P15056 | 9/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4362964 | 0.86 | KDR (0.73) | KDRLCKCSF1RIGF1RMET | |
| SCHEMBL5788828 | 0.85 | KDR (0.66) | KDRLCKCSF1RIGF1RMET | |
| SCHEMBL4374616 | 0.85 | KDR (0.66) | KDRLCKCSF1RIGF1RMET | |
| SCHEMBL4363892 | 0.81 | KDR (1.00) | KDRLCKCSF1RIGF1RMET | |
| SCHEMBL4372473 | 0.78 | KDR (0.84) | KDRLCKCSF1RIGF1RMET | |
| SCHEMBL5790703 | 0.77 | KDR (0.70) | KDRLCKCSF1RIGF1RMET | |
| SCHEMBL4367198 | 0.77 | KDR (0.68) | KDRLCKCSF1RIGF1RMET | |
| SCHEMBL5787928 | 0.77 | KDR (0.85) | KDRLCKCSF1RIGF1RMET | |
| SCHEMBL5820367 | 0.76 | KDR (0.69) | KDRLCKCSF1RIGF1RMET | |
| SCHEMBL5820360 | 0.76 | KDR (0.69) | KDRLCKCSF1RIGF1RMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638954-A1 | FUSED AZOLES SUCH AS 2,5-DISUBSTITUTED BENZIMIDAZOLES, BENZOXAZOLES AND BENZOTHIAZOLES AS KINASE INHIBITORS | AMGEN INC. (US) | 2006-03-29 | — | — | EP | disclosed |
| WO-2004085425-A1 | FUSED AZOLES SUCH AS 2,5-DISUBSTITUTED BENZIMIDAZOLES, BENZOXAZOLES AND BENZOTHIAZOLES AS KINASE INHIBITORS | AMGEN INC (US) | 2004-10-07 | — | — | WO | disclosed |