Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | NISCH | Q9Y2I1 | 4/20 | 0.45 |
| ▸ | MC4R | P32245 | 1/20 | 0.45 |
| ▸ | CD274 | Q9NZQ7 | 10/20 | 0.43 |
| ▸ | PDCD1LG2 | Q9BQ51 | 9/20 | 0.43 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4818042 | 0.79 | KCNH2 (0.58) | KCNH2NISCHMC4R | |
| SCHEMBL4823049 | 0.77 | KCNH2 (0.57) | KCNH2NISCHMC4RCD274PDCD1 | |
| SCHEMBL4823684 | 0.76 | KCNH2 (0.75) | KCNH2NISCHMC4RCD274PDCD1LG2 | |
| SCHEMBL4822652 | 0.76 | KCNH2 (0.73) | KCNH2NISCHMC4RCD274PDCD1LG2 | |
| SCHEMBL4822543 | 0.75 | KCNH2 (0.82) | KCNH2MC4RCD274PDCD1LG2 | |
| SCHEMBL4823295 | 0.75 | KCNH2 (0.53) | KCNH2NISCHMC4RMAOAMAOB | |
| SCHEMBL4071377 | 0.74 | KCNH2 (1.00) | KCNH2MC4R | |
| SCHEMBL4819225 | 0.72 | KCNH2 (0.73) | KCNH2NISCHMC4RMAOAMAOB | |
| SCHEMBL4817708 | 0.72 | KCNH2 (0.69) | KCNH2NISCHMC4RMAOAMAOB | |
| SCHEMBL4824330 | 0.71 | KCNH2 (0.68) | KCNH2NISCHMC4RMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644337-A1 | MELANOCORTIN-4 RECEPTOR BINDING COMPOUNDS AND METHODS OF USE THEREOF | Gene Logic, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005121100-A1 | MELANOCORTIN-4 RECEPTOR BINDING COMPOUNDS AND METHODS OF USE THEREOF | GENE LOGIC INC. (US) | 2005-12-22 | — | — | WO | disclosed |