Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XIAP | P98170 | 13/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5792454 | 1.00 | XIAP (0.42) | XIAPRIPK1HDAC4SMN1; SMN2TAAR1 | |
| SCHEMBL5795121 | 1.00 | XIAP (0.42) | XIAPRIPK1HDAC4SMN1; SMN2TAAR1 | |
| SCHEMBL5793810 | 0.81 | KDM1A (0.47) | RIPK1HDAC4SMN1; SMN2OPRK1ALDH1A1 | |
| SCHEMBL5793048 | 0.81 | KDM1A (0.47) | RIPK1HDAC4SMN1; SMN2OPRK1ALDH1A1 | |
| SCHEMBL4845005 | 0.77 | PSEN1 (0.51) | — | |
| SCHEMBL4841506 | 0.77 | PSEN1 (0.51) | — | |
| SCHEMBL4841310 | 0.77 | PSEN1 (0.51) | — | |
| SCHEMBL4841228 | 0.77 | PSEN1 (0.51) | — | |
| SCHEMBL4833871 | 0.77 | PSEN1 (0.53) | — | |
| SCHEMBL5791890 | 0.77 | XIAP (0.43) | XIAPHDAC4SMN1; SMN2TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636196-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | claimed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | claimed |
| EP-1636196-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | disclosed |