Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | CDK2 | P24941 | 9/20 | 0.44 |
| ▸ | CDK4 | P11802 | 4/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.44 |
| ▸ | CDK19 | Q9BWU1 | 2/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.42 |
| ▸ | OGA | O60502 | 1/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | MATK | P42679 | 1/20 | 0.41 |
| ▸ | FRK | P42685 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL413728 | 0.97 | HDAC1 (0.49) | HDAC1CDK2CDK4CCNE1MKNK1 | |
| SCHEMBL408673 | 0.94 | HDAC1 (0.53) | HDAC1CDK2CDK4CCNE1MKNK1 | |
| SCHEMBL3360699 | 0.91 | HDAC1 (0.54) | HDAC1CDK2CDK4CCNE1MKNK1 | |
| SCHEMBL409778 | 0.82 | CDK2 (0.57) | HDAC1CDK2CDK4CCNE1CDK19 | |
| SCHEMBL413474 | 0.82 | CDK2 (0.47) | HDAC1CDK2CDK4CCNE1CDK19 | |
| SCHEMBL415283 | 0.80 | CDK2 (0.49) | HDAC1CDK2CDK4CCNE1DYRK3 | |
| SCHEMBL413670 | 0.80 | CDK19 (0.49) | HDAC1CDK2CDK4CCNE1MKNK1 | |
| SCHEMBL412332 | 0.80 | DYRK3 (0.54) | HDAC1CDK2CDK4CCNE1MKNK1 | |
| SCHEMBL414098 | 0.79 | CDK2 (0.48) | HDAC1CDK2CDK4CCNE1DYRK3 | |
| SCHEMBL407989 | 0.78 | CDK2 (0.48) | HDAC1CDK2CDK4CCNE1CDK19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546112-A4 | IMIDAZOLOPYRIDINES AND METHODS OF MAKING AND USING THE SAME | BIOGEN IDEC INC (US) | 2006-06-07 | — | — | EP | claimed |
| EP-1546112-A2 | IMIDAZOLOPYRIDINES AND METHODS OF MAKING AND USING THE SAME | Biogen Idec MA Inc. (US) | 2005-06-29 | — | — | EP | claimed |
| WO-2004021989-A2 | IMIDAZOLOPYRIDINES AND METHODS OF MAKING AND USING THE SAME | BIOGEN IDEC MA INC. (US) | 2004-03-18 | — | — | WO | claimed |