Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 4/20 | 0.36 |
| ▸ | KDR | P35968 | 3/20 | 0.35 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 4/20 | 0.34 |
| ▸ | EHMT2 | Q96KQ7 | 3/20 | 0.34 |
| ▸ | DNMT1 | P26358 | 2/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 4/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridine SCHEMBL5795752 | 0.96 | IGF1R (0.41) | IGF1REGFRKDREPHA2EPHB4 | |
| SCHEMBL1748713 | 0.95 | IGF1R (0.46) | IGF1RKDREPHA2EPHB4AXL | |
| SCHEMBL1748700 | 0.88 | IGF1R (0.53) | IGF1REGFRKDREPHA2EPHB4 | |
| SCHEMBL5797454 | 0.86 | IGF1R (0.45) | IGF1REGFRKDREPHA2EPHB4 | |
| Pyridine SCHEMBL5795805 | 0.84 | IGF1R (0.51) | IGF1REGFRKDREPHA2EPHB4 | |
| SCHEMBL4493773 | 0.83 | IGF1R (0.46) | IGF1REGFRKDREPHA2EPHB4 | |
| SCHEMBL5795300 | 0.83 | IGF1R (0.47) | IGF1REGFRKDREPHA2EPHB4 | |
| SCHEMBL1748714 | 0.82 | IGF1R (0.47) | IGF1REGFRKDREPHA2EPHB4 | |
| SCHEMBL1748784 | 0.79 | IGF1R (0.50) | IGF1REGFRKDREPHA2EPHB4 | |
| SCHEMBL4496734 | 0.79 | IGF1R (0.49) | IGF1REGFRKDREPHA2EPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732546-A2 | NOVEL PYRROLO (2,3-B)PYRIDINE DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF IN THE FORM OF KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005095399-A2 | NOVEL PYRROLO (2,3-B)PYRIDINE DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF IN THE FORM OF KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2005-10-13 | — | — | WO | disclosed |