Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.53 |
| ▸ | RAF1 | P04049 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | KIT | P10721 | 1/20 | 0.53 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.53 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.53 |
| ▸ | FLT1 | P17948 | 3/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5806801 | 0.90 | KDR (0.56) | KDRRAF1LCKRETCYP3A4 | |
| SCHEMBL5797537 | 0.87 | KDR (0.55) | KDRRAF1LCKRETCYP3A4 | |
| SCHEMBL5797526 | 0.86 | KDR (0.49) | KDRRAF1LCKRETCYP3A4 | |
| SCHEMBL5796662 | 0.83 | KDR (0.54) | KDRRAF1LCKRETCYP3A4 | |
| SCHEMBL5797032 | 0.83 | KDR (0.49) | KDRRAF1LCKRETCYP3A4 | |
| SCHEMBL5797491 | 0.82 | KDR (0.51) | KDRRAF1LCKRETCYP3A4 | |
| SCHEMBL5794302 | 0.82 | KDR (0.51) | KDRRAF1LCKRETCYP3A4 | |
| SCHEMBL4850925 | 0.81 | KDR (0.61) | KDRRAF1LCKRETCYP3A4 | |
| SCHEMBL5797253 | 0.80 | KDR (0.50) | KDRRAF1LCKRETCYP3A4 | |
| SCHEMBL5796355 | 0.80 | KDR (0.56) | KDRRAF1LCKRETCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006034075-A1 | (HYDRAZIDO) (AMINO) THIOPHENE COMPOUNDS | OSI PHARMACEUTICALS, INC. (US) | 2006-03-30 | — | — | WO | claimed |
| WO-2006034075-A1 | (HYDRAZIDO) (AMINO) THIOPHENE COMPOUNDS | OSI PHARMACEUTICALS, INC. (US) | 2006-03-30 | — | — | WO | disclosed |