Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 11/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 5/20 | 0.35 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.35 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5796955 | 0.88 | FFAR1 (0.36) | FFAR1PPARGDHFR | |
| SCHEMBL5795879 | 0.82 | PARP1 (0.38) | DHFR | |
| SCHEMBL4690844 | 0.81 | PLA2G10 (0.40) | FFAR1CDK2PPARGDHFRPLA2G10 | |
| SCHEMBL5799326 | 0.81 | FFAR1 (0.43) | FFAR1DHFRPLA2G10 | |
| SCHEMBL4691250 | 0.71 | MAP4K4 (0.42) | FFAR1IKBKBCHUKDHFR | |
| SCHEMBL4691075 | 0.71 | CDK2 (0.48) | CDK2IKBKBCHUKDHFRPLA2G10 | |
| SCHEMBL5798206 | 0.69 | — | — | |
| SCHEMBL4693946 | 0.67 | PARP1 (0.42) | DHFR | |
| SCHEMBL4688624 | 0.64 | FFAR1 (0.40) | FFAR1DHFRPLA2G10PLA2G2ASLCO1B1 | |
| SCHEMBL21484487 | 0.64 | FFAR1 (0.91) | FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628979-A1 | DIAMINOPYRROLOQUINAZOLINES COMPOUNDS AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-01 | — | — | EP | claimed |
| WO-2004101568-A1 | DIAMINOPYRROLOQUINAZOLINES COMPOUNDS AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-11-25 | — | — | WO | claimed |