SCHEMBL579790

SCHEMBL579790

O=CC(Br)c1ccc(-c2ccc([C@@H](Br)C=O)cc2)cc1

nearest known ligand 0.31

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ACP3 P15309 2/20 0.31
PTGS2 P35354 1/20 0.31
TYR P14679 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1440680 1.00 ACP3 (0.31) ACP3PTGS2TYR
SCHEMBL3246785 0.91 ACP3 (0.44) ACP3PTGS2
SCHEMBL22590138 0.82 CYP2A6 (0.40)
SCHEMBL321965 0.82 CYP2A6 (0.40)
SCHEMBL21597319 0.80 CYP2A6 (0.42) TYR
SCHEMBL20550831 0.80 IDO1 (0.38)
SCHEMBL1505157 0.80 TYR (0.54) TYR
SCHEMBL21834675 0.80 ESR1 (0.44) TYR
SCHEMBL191880 0.80 GSK3B (0.40)
SCHEMBL168223 0.80 IDO1 (0.38)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016079697-A1 PROCESS FOR THE PREPARATION OF AN INTERMEDIATE OF DACLATASVIR DIHYDROCHLORIDE SUN PHARMACEUTICAL INDUSTRIES LIMITED (IN) 2016-05-26 WO disclosed
EP-3019196-A1 COMBINATIONS OF HEPATITIS C VIRUS INHIBITORS Bristol-Myers Squibb Company (US) 2016-05-18 EP disclosed
WO-2015005901-A1 COMBINATIONS OF HEPATITIS C VIRUS INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2015-01-15 WO disclosed
EP-2417126-A1 HEPATITIS C VIRUS INHIBITORS Bristol-Myers Squibb Company (US) 2012-02-15 EP disclosed
WO-2010117977-A1 HEPATITIS C VIRUS INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2010-10-14 WO disclosed