Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TTK | P33981 | 3/20 | 0.38 |
| ▸ | DHODH | Q02127 | 3/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | BPTF | Q12830 | 1/20 | 0.36 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.36 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5796502 | 0.91 | MEN1 (0.43) | KMT2AMEN1LMNASMN1; SMN2TTK | |
| SCHEMBL4913037 | 0.79 | KDM4E (0.50) | KMT2AMEN1KDM4EALDH1A1MAPT | |
| SCHEMBL4900772 | 0.79 | KCNH2 (0.41) | KMT2AMEN1KDM4EALDH1A1MAPT | |
| SCHEMBL4901251 | 0.79 | BCDIN3D (0.45) | KMT2AMEN1KDM4EALDH1A1MAPT | |
| SCHEMBL4910942 | 0.77 | HTR2A (0.46) | KMT2AMEN1KDM4EALDH1A1MAPT | |
| SCHEMBL4913021 | 0.77 | BRD4 (0.40) | KMT2AMEN1KDM4EALDH1A1MAPT | |
| SCHEMBL14281210 | 0.74 | MEN1 (0.41) | KMT2AMEN1KDM4EALDH1A1MAPT | |
| SCHEMBL4909185 | 0.74 | GAA (0.43) | KMT2AMEN1MAPTSMN1; SMN2BRD4 | |
| SCHEMBL4909812 | 0.73 | HTR2A (0.41) | KMT2AMEN1HTR2A | |
| SCHEMBL4908676 | 0.72 | HTR2A (0.45) | KMT2AMEN1KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006060762-A2 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2006-06-08 | — | — | WO | disclosed |