Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.63 |
| ▸ | CTNNB1 | P35222 | 6/20 | 0.59 |
| ▸ | WNT3A | P56704 | 6/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1419814 | 1.00 | AR (0.63) | ARCTNNB1WNT3AROCK2ROCK1 | |
| SCHEMBL29949712 | 1.00 | AR (0.63) | ARCTNNB1WNT3AROCK2ROCK1 | |
| Hydrochloric Acid SCHEMBL14994256 | 0.98 | AR (0.61) | ARCTNNB1WNT3AROCK2ROCK1 | |
| Hydrochloric Acid SCHEMBL30177200 | 0.98 | AR (0.61) | ARCTNNB1WNT3AROCK2ROCK1 | |
| Trifluoroacetic Acid SCHEMBL18108734 | 0.89 | AR (0.54) | ARCTNNB1WNT3AROCK2ROCK1 | |
| Trifluoroacetic Acid SCHEMBL18108738 | 0.89 | AR (0.54) | ARCTNNB1WNT3AROCK2ROCK1 | |
| Urethane SCHEMBL5780178 | 0.86 | CTNNB1 (0.55) | ARCTNNB1WNT3AROCK2ROCK1 | |
| SCHEMBL29887527 | 0.86 | AR (0.63) | ARKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL475069 | 0.86 | AR (0.63) | ARKDM4EMEN1ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL31173861 | 0.84 | AR (0.61) | ARKDM4EMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1618093-A2 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | Signal Pharmaceuticals LLC (US) | 2006-01-25 | — | — | EP | disclosed |
| WO-2004094388-A2 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-11-04 | — | — | WO | disclosed |