Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 16/20 | 0.64 |
| ▸ | PIM1 | P11309 | 3/20 | 0.58 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.58 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3291603 | 1.00 | HPGD (0.64) | HPGDPIM1PIM2AKR1B1NPC1 | |
| SCHEMBL2174763 | 0.88 | PIM1 (0.63) | HPGDPIM1PIM2AKR1B1 | |
| SCHEMBL2785238 | 0.88 | PIM1 (0.63) | HPGDPIM1PIM2AKR1B1 | |
| SCHEMBL2546776 | 0.85 | PIM1 (0.69) | HPGDPIM1PIM2AKR1B1NPC1 | |
| SCHEMBL2173332 | 0.83 | HPGD (0.56) | HPGDPIM1PIM2 | |
| SCHEMBL2785066 | 0.83 | HPGD (0.56) | HPGDPIM1PIM2 | |
| SCHEMBL2172862 | 0.83 | HPGD (0.68) | HPGD | |
| SCHEMBL2174556 | 0.83 | PDE4B (0.68) | HPGDPIM1PIM2 | |
| SCHEMBL2786377 | 0.83 | HPGD (0.68) | HPGD | |
| SCHEMBL2171889 | 0.80 | HPGD (0.66) | HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006069186-A2 | SMALL MOLECULE BCL-XL/BCL-2 BINDING INHIBITORS | THE OHIO STATE RESEARCH FOUNDATION (US) | 2006-06-29 | — | — | WO | disclosed |
| WO-2006069217-A2 | SMALL MOLECULE CYCLIN D1 ABLATIVE AGENTS | THE OHIO STATE RESEARCH FOUNDATION (US) | 2006-06-29 | — | — | WO | disclosed |