Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 2/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | XBP1 | P17861 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3202651 | 0.92 | CA14 (0.51) | CA14CA12DGAT1SMN1; SMN2CA1 | |
| SCHEMBL3725616 | 0.88 | CA12 (0.42) | CA14CA12DGAT1CA1CA2 | |
| SCHEMBL3728417 | 0.88 | CA12 (0.42) | CA14CA12DGAT1CA1CA2 | |
| SCHEMBL3725618 | 0.88 | CA12 (0.42) | CA14CA12DGAT1CA1CA2 | |
| Hydrochloric Acid SCHEMBL31645354 | 0.86 | CA12 (0.41) | CA14CA12DGAT1CA1CA2 | |
| Hydrochloric Acid SCHEMBL5753572 | 0.86 | CA12 (0.41) | CA14CA12DGAT1CA1CA2 | |
| Hydrochloric Acid SCHEMBL18342541 | 0.86 | CA12 (0.41) | CA14CA12DGAT1CA1CA2 | |
| SCHEMBL3193209 | 0.82 | CA12 (0.39) | CA14CA12DGAT1CA1CA2 | |
| SCHEMBL15618162 | 0.82 | CA12 (0.39) | CA14CA12DGAT1CA1CA2 | |
| SCHEMBL801212 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636218-A1 | THIAZOLYLPIPERIDINE DERIVATIVES AS MTP INHIBITORS | MERCK PATENT GmbH (DE) | 2006-03-22 | — | — | EP | disclosed |
| WO-2005003128-A1 | THIAZOLYLPIPERIDINE DERIVATIVES AS MTP INHIBITORS | MERCK PATENT GMBH (DE) | 2005-01-13 | — | — | WO | disclosed |