Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Valine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.41 |
| ▸ | PRCP | P42785 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 2/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.32 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.32 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.32 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Valine SCHEMBL2189978 | 1.00 | SLC7A5 (0.41) | SLC7A5PRCPNOS2NOS3NOS1 | |
| Valine SCHEMBL4612496 | 1.00 | SLC7A5 (0.41) | SLC7A5PRCPNOS2NOS3NOS1 | |
| Valine SCHEMBL3048383 | 1.00 | SLC7A5 (0.41) | SLC7A5PRCPNOS2NOS3NOS1 | |
| Valine SCHEMBL4612513 | 0.97 | SLC7A5 (0.43) | SLC7A5PRCPNOS2NOS3NOS1 | |
| Valine SCHEMBL3100209 | 0.97 | SLC7A5 (0.43) | SLC7A5PRCPNOS2NOS3NOS1 | |
| Valine SCHEMBL3496376 | 0.97 | SLC7A5 (0.43) | SLC7A5PRCPNOS2NOS3NOS1 | |
| Valine SCHEMBL4613217 | 0.97 | SLC7A5 (0.43) | SLC7A5PRCPNOS2NOS3NOS1 | |
| Valine SCHEMBL3498554 | 0.97 | SLC7A5 (0.43) | SLC7A5PRCPNOS2NOS3NOS1 | |
| Valine SCHEMBL1675269 | 0.97 | SLC7A5 (0.43) | SLC7A5PRCPNOS2NOS3NOS1 | |
| Valine SCHEMBL84548 | 0.97 | SLC7A5 (0.43) | SLC7A5PRCPNOS2NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006048339-A2 | COSMETIC COMPOSITION COMRISING AN ACTIVE AGENT AND A UREA COMPOUND | L'ORÉAL (FR) | 2006-05-11 | — | — | WO | claimed |
| EP-1064010-A4 | PEPTIDE COMPOSITIONS AND FORMULATIONS AND USE OF SAME | CONNECTIVE TISSUE IMAGINEERING (US) | 2004-10-06 | — | — | EP | claimed |
| EP-1064010-A1 | PEPTIDE COMPOSITIONS AND FORMULATIONS AND USE OF SAME | Mrs, Llc (US) | 2001-01-03 | — | — | EP | claimed |
| WO-1999045941-A1 | PEPTIDE COMPOSITIONS AND FORMULATIONS AND USE OF SAME | MRS, LLC (US) | 1999-09-16 | — | — | WO | claimed |