Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5203421 | 0.88 | HTT (0.45) | HTTCYP11B1CYP11B2GRM5RAF1 | |
| SCHEMBL248926 | 0.88 | — | — | |
| SCHEMBL30603171 | 0.88 | — | — | |
| SCHEMBL29919144 | 0.88 | — | — | |
| SCHEMBL2642286 | 0.88 | — | — | |
| SCHEMBL7172966 | 0.78 | HTT (0.38) | HTTCYP11B1CYP11B2GRM5RAF1 | |
| SCHEMBL116722 | 0.77 | — | — | |
| Cyanide SCHEMBL27868730 | 0.76 | KDM4E (0.39) | HTTCYP11B1CYP11B2KDM4EPOLB | |
| Bromide SCHEMBL1454620 | 0.75 | KMT2A (0.41) | HTTMAP4K4KDM4EPOLBHCAR2 | |
| SCHEMBL6656331 | 0.75 | POLB (0.50) | HTTCYP11B2KDM4EPOLBHCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006067445-A2 | CSF-1R KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2006-06-29 | — | — | WO | disclosed |