Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.79 |
| ▸ | MEN1 | O00255 | 2/20 | 0.79 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.79 |
| ▸ | APAF1 | O14727 | 1/20 | 0.79 |
| ▸ | NPC1 | O15118 | 1/20 | 0.79 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.79 |
| ▸ | MAPT | P10636 | 1/20 | 0.79 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.79 |
| ▸ | HTT | P42858 | 1/20 | 0.79 |
| ▸ | RAB9A | P51151 | 1/20 | 0.79 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.79 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.79 |
| ▸ | FDPS | P14324 | 13/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PON1 | P27169 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL582481 | 0.98 | SMN1; SMN2 (0.82) | SMN1; SMN2MEN1HSP90AA1KMT2AAPAF1 | |
| Bromide SCHEMBL28854102 | 0.96 | SMN1; SMN2 (0.79) | SMN1; SMN2MEN1HSP90AA1KMT2AAPAF1 | |
| Hydrochloric Acid SCHEMBL20957483 | 0.96 | MEN1 (0.79) | SMN1; SMN2MEN1HSP90AA1KMT2AAPAF1 | |
| Hydrochloric Acid SCHEMBL28693882 | 0.96 | MEN1 (0.79) | SMN1; SMN2MEN1HSP90AA1KMT2AAPAF1 | |
| Hydrochloric Acid SCHEMBL28557738 | 0.96 | MEN1 (0.79) | SMN1; SMN2MEN1HSP90AA1KMT2AAPAF1 | |
| Bromide SCHEMBL29094221 | 0.96 | MEN1 (0.79) | SMN1; SMN2MEN1HSP90AA1KMT2AAPAF1 | |
| Bromide SCHEMBL30954387 | 0.96 | SMN1; SMN2 (0.85) | SMN1; SMN2MEN1HSP90AA1KMT2AAPAF1 | |
| Bromide SCHEMBL232599 | 0.96 | SMN1; SMN2 (0.85) | SMN1; SMN2MEN1HSP90AA1KMT2AAPAF1 | |
| Bromide SCHEMBL33530134 | 0.94 | SMN1; SMN2 (0.82) | SMN1; SMN2MEN1HSP90AA1KMT2AAPAF1 | |
| Bromide SCHEMBL33528969 | 0.94 | SMN1; SMN2 (0.82) | SMN1; SMN2MEN1HSP90AA1KMT2AAPAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10626335-B2 | Process for removing metals from hydrocarbons | PETROLIAM NASIONAL BERHAD (PETRONAS) (MY) | 2020-04-21 | — | — | US | disclosed |
| EP-2417225-B1 | PROCESS FOR REMOVING MERCURY FROM HYDROCARBONS | PETROLIAM NASIONAL BERHAD PETRONAS (MY) | 2020-03-11 | — | — | EP | disclosed |
| US-20120121485-A1 | PROCESS FOR REMOVING METALS FROM HYDROCARBONS | PETROLIAM NASIONAL BERHAD (PETRONAS) (MY) | 2012-05-17 | — | — | US | disclosed |
| EP-2417225-A2 | PROCESS FOR REMOVING METALS FROM HYDROCARBONS | Petroliam Nasional Berhad (PETRONAS) (MY) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010116165-A2 | PROCESS FOR REMOVING METALS FROM HYDROCARBONS | PETROLIAM NASIONAL BERHAD (PETRONAS) (MY) | 2010-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10626335-B2 | Process for removing metals from hydrocarbons | SHH, AHR, HTT | SMN1; SMN2 828/4885MEN1 353/4885HSP90AA1 4020/4885 |
| US-20120121485-A1 | PROCESS FOR REMOVING METALS FROM HYDROCARBONS | SHH, AHR, HTT | SMN1; SMN2 828/4885MEN1 353/4885HSP90AA1 4020/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.