Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 13/20 | 0.52 |
| ▸ | KDR | P35968 | 10/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 12/20 | 0.48 |
| ▸ | AURKA | O14965 | 10/20 | 0.48 |
| ▸ | TPX2 | Q9ULW0 | 6/20 | 0.48 |
| ▸ | LCK | P06239 | 5/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL580587 | 0.77 | TEK (0.44) | TEKKDRAURKBAURKATPX2 | |
| SCHEMBL1264679 | 0.75 | TEK (0.64) | TEKKDRAURKBAURKATPX2 | |
| SCHEMBL4767675 | 0.74 | TEK (0.42) | TEKKDRAURKBAURKATPX2 | |
| SCHEMBL580441 | 0.73 | TEK (0.45) | TEKKDRAURKBAURKATPX2 | |
| SCHEMBL1265828 | 0.72 | TEK (0.56) | TEKKDRAURKBAURKATPX2 | |
| SCHEMBL580771 | 0.72 | TEK (0.46) | TEKKDRAURKBAURKATPX2 | |
| SCHEMBL581733 | 0.72 | AURKB (0.51) | TEKKDRAURKBAURKATPX2 | |
| SCHEMBL580453 | 0.71 | TEK (0.47) | TEKKDRAURKBAURKATPX2 | |
| SCHEMBL5262625 | 0.71 | TEK (0.61) | TEKKDRAURKBAURKATPX2 | |
| SCHEMBL5259299 | 0.70 | TEK (0.79) | TEKKDRAURKBAURKATPX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984353-B1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC (US) | 2015-12-30 | — | — | EP | disclosed |
| EP-2418209-B1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC (US) | 2014-06-25 | — | — | EP | disclosed |
| EP-2418209-A1 | Aurora kinase modulators and method of use | Amgen Inc. (US) | 2012-02-15 | — | — | EP | disclosed |