Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 9/20 | 0.65 |
| ▸ | AURKA | O14965 | 5/20 | 0.65 |
| ▸ | TPX2 | Q9ULW0 | 4/20 | 0.65 |
| ▸ | TEK | Q02763 | 9/20 | 0.49 |
| ▸ | KDR | P35968 | 6/20 | 0.48 |
| ▸ | LCK | P06239 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | YES1 | P07947 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL580534 | 0.94 | AURKB (0.60) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL580448 | 0.93 | AURKB (0.60) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL580601 | 0.92 | AURKB (0.76) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL580462 | 0.91 | AURKB (0.66) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL580474 | 0.91 | AURKB (0.66) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL581232 | 0.91 | AURKB (0.76) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL580672 | 0.91 | AURKB (0.65) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL580481 | 0.90 | AURKB (0.76) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL580935 | 0.89 | AURKB (0.65) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL581296 | 0.89 | AURKB (0.63) | AURKBAURKATPX2TEKABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984353-B1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC (US) | 2015-12-30 | — | — | EP | disclosed |
| EP-2418209-B1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC (US) | 2014-06-25 | — | — | EP | disclosed |
| EP-2418209-A1 | Aurora kinase modulators and method of use | Amgen Inc. (US) | 2012-02-15 | — | — | EP | disclosed |