Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 14/20 | 0.76 |
| ▸ | PIK3CG | P48736 | 13/20 | 0.76 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.76 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.76 |
| ▸ | PI4KB | Q9UBF8 | 5/20 | 0.76 |
| ▸ | CLK2 | P49760 | 2/20 | 0.76 |
| ▸ | CLK1 | P49759 | 1/20 | 0.76 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.35 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1783626 | 0.86 | PIK3CD (1.00) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL1886594 | 0.81 | PIK3CD (0.60) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL6550749 | 0.80 | PIK3CD (0.61) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL1888590 | 0.79 | PIK3CD (0.67) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL2256898 | 0.79 | PIK3CD (0.85) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL30020291 | 0.79 | PIK3CD (0.85) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL1787414 | 0.78 | PIK3CD (0.85) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL1786035 | 0.78 | PIK3CG (0.84) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL2360519 | 0.77 | PIK3CD (0.64) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL5786761 | 0.76 | PIK3CD (0.64) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689391-A2 | 5-PHENYL-4-METHYL-THIAZOL-2-YL-AMINE DERIVATIVES AS INHIBITORS OF PHOSPHATIDYLINOSITOL 3 KINASE ENZYMES (PI3) FOR THE TREATMENT OF INFLAMMATORY AIRWAY DISEASES | Novartis AG (CH) | 2006-08-16 | — | — | EP | disclosed |
| WO-2005021519-A2 | 5-PHENYL-4-METHYL-THIAZOL-2-YL-AMINE DERIVATIVES AS INHIBITORS OF PHOSPHATIDYLINOSITOL 3 KINASE ENZYMES (PI3) FOR THE TREATMENT OF INFLAMMATORY AIRWAY DISEASES | NOVARTIS AG (CH) | 2005-03-10 | — | — | WO | disclosed |