Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 16/20 | 0.68 |
| ▸ | PIK3CG | P48736 | 15/20 | 0.68 |
| ▸ | PIK3CA | P42336 | 13/20 | 0.68 |
| ▸ | PIK3CB | P42338 | 11/20 | 0.68 |
| ▸ | PI4KB | Q9UBF8 | 7/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | PIK3C2A | O00443 | 3/20 | 0.40 |
| ▸ | PIK3C2B | O00750 | 3/20 | 0.40 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.40 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.39 |
| ▸ | PI4KA | P42356 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5134573 | 0.89 | PIK3CD (0.66) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL1783913 | 0.84 | PIK3CD (0.68) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL1783906 | 0.84 | PIK3CD (0.68) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL1785140 | 0.84 | PIK3CD (0.70) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL1789102 | 0.84 | PIK3CD (0.70) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL1785137 | 0.84 | PIK3CD (0.70) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL1783570 | 0.82 | PIK3CD (0.70) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL1783567 | 0.82 | PIK3CD (0.70) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL48634 | 0.81 | PIK3CG (1.00) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL1786468 | 0.81 | PIK3CD (0.74) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689391-A2 | 5-PHENYL-4-METHYL-THIAZOL-2-YL-AMINE DERIVATIVES AS INHIBITORS OF PHOSPHATIDYLINOSITOL 3 KINASE ENZYMES (PI3) FOR THE TREATMENT OF INFLAMMATORY AIRWAY DISEASES | Novartis AG (CH) | 2006-08-16 | — | — | EP | disclosed |
| WO-2005021519-A2 | 5-PHENYL-4-METHYL-THIAZOL-2-YL-AMINE DERIVATIVES AS INHIBITORS OF PHOSPHATIDYLINOSITOL 3 KINASE ENZYMES (PI3) FOR THE TREATMENT OF INFLAMMATORY AIRWAY DISEASES | NOVARTIS AG (CH) | 2005-03-10 | — | — | WO | disclosed |