Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 10/20 | 0.57 |
| ▸ | AURKA | O14965 | 6/20 | 0.57 |
| ▸ | TPX2 | Q9ULW0 | 6/20 | 0.57 |
| ▸ | TEK | Q02763 | 8/20 | 0.53 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL580237 | 0.98 | AURKB (0.57) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL581575 | 0.89 | AURKB (0.71) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL580723 | 0.89 | AURKB (0.71) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL580629 | 0.88 | AURKB (0.72) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL581754 | 0.86 | AURKB (0.61) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL581544 | 0.84 | AURKB (0.61) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL580890 | 0.84 | AURKB (0.66) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL581232 | 0.84 | AURKB (0.76) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL580505 | 0.84 | AURKB (0.66) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL580474 | 0.82 | AURKB (0.66) | AURKBAURKATPX2TEKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984353-B1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC (US) | 2015-12-30 | — | — | EP | disclosed |
| EP-2418209-B1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC (US) | 2014-06-25 | — | — | EP | disclosed |
| EP-2418209-A1 | Aurora kinase modulators and method of use | Amgen Inc. (US) | 2012-02-15 | — | — | EP | disclosed |