Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.76 |
| ▸ | PRKDC | P78527 | 2/20 | 0.56 |
| ▸ | EGFR | P00533 | 2/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.55 |
| ▸ | BTK | Q06187 | 3/20 | 0.52 |
| ▸ | AURKA | O14965 | 4/20 | 0.51 |
| ▸ | RHOA | P61586 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | CCND1 | P24385 | 1/20 | 0.47 |
| ▸ | CCND2 | P30279 | 1/20 | 0.47 |
| ▸ | CCND3 | P30281 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5803243 | 0.84 | GSK3B (0.76) | GSK3BPRKDCEGFRFGFR1BTK | |
| SCHEMBL13763871 | 0.74 | AURKA (0.78) | GSK3BEGFRFGFR1AURKARHOA | |
| SCHEMBL1599121 | 0.73 | GSK3B (1.00) | GSK3BPRKDCEGFRADORA2ACDK4 | |
| SCHEMBL5803855 | 0.73 | GSK3B (1.00) | GSK3BPRKDCEGFRFGFR1BTK | |
| SCHEMBL5803009 | 0.73 | GSK3B (0.72) | GSK3BPRKDCEGFRFGFR1ADORA2A | |
| SCHEMBL30030206 | 0.72 | PRKDC (0.67) | GSK3BPRKDCADORA2A | |
| SCHEMBL30030843 | 0.72 | PRKDC (0.67) | GSK3BPRKDCADORA2A | |
| SCHEMBL5815034 | 0.72 | GSK3B (0.71) | GSK3BPRKDCEGFRFGFR1BTK | |
| SCHEMBL5764437 | 0.71 | FGFR1 (1.00) | EGFRFGFR1BTK | |
| SCHEMBL29651071 | 0.70 | GSK3B (0.64) | GSK3BPRKDCADORA2AGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006091737-A1 | MODULATORS OF GSK-3 ACTIVITY | KEMIA, INC. (US) | 2006-08-31 | — | — | WO | disclosed |