SCHEMBL5807155

SCHEMBL5807155

Cc1c(C)n(Cc2ccc(Cl)c(Cl)c2)c2c(OCC(C)C)nccc12

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGDR2 Q9Y5Y4 1/20 0.39
TYMS P04818 1/20 0.35
SMN1; SMN2 Q16637 4/20 0.34
HTT P42858 3/20 0.34
NPSR1 Q6W5P4 2/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
NPC1 O15118 1/20 0.34
JAK2 O60674 1/20 0.34
RAB9A P51151 1/20 0.34
HKDC1 Q2TB90 1/20 0.34
CCR2 P41597 3/20 0.34
ALDH1A1 P00352 2/20 0.34
LMNA P02545 2/20 0.34
TP53 P04637 1/20 0.34
TSHR P16473 1/20 0.34
ABCB11 O95342 1/20 0.34
HCRTR2 O43614 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL5810686 0.99 PTGDR2 (0.39) PTGDR2TYMSSMN1; SMN2HTTNPSR1
SCHEMBL5810860 0.89 KDM4E (0.38) PTGDR2SMN1; SMN2HTTALDH1A1LMNA
Hydrochloric Acid SCHEMBL5807516 0.89 PTGDR2 (0.38) PTGDR2TYMSSMN1; SMN2HTTNPSR1
Hydrochloric Acid SCHEMBL5809996 0.88 KDM4E (0.37) PTGDR2SMN1; SMN2HTTALDH1A1LMNA
SCHEMBL5809806 0.88 MCL1 (0.38) PTGDR2SMN1; SMN2ALDH1A1TSHRHCRTR2
SCHEMBL5806243 0.86 PTGDR2 (0.42) PTGDR2TYMSSMN1; SMN2HTTNPSR1
Hydrochloric Acid SCHEMBL5807333 0.86 MCL1 (0.38) PTGDR2SMN1; SMN2NPSR1ALDH1A1LMNA
SCHEMBL5811354 0.86 MEN1 (0.42) PTGDR2HTTALDH1A1LMNAMAPT
Hydrochloric Acid SCHEMBL5808605 0.85 PTGDR2 (0.41) PTGDR2TYMSSMN1; SMN2HTTNPSR1
SCHEMBL5806009 0.85 CYP1A2 (0.39) HTTCYP1A2CYP3A4CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006025717-A1 PYRROLO[2,3-c]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORPORATION (KR) 2006-03-09 WO claimed