Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 14/20 | 0.54 |
| ▸ | AURKA | O14965 | 10/20 | 0.54 |
| ▸ | TPX2 | Q9ULW0 | 5/20 | 0.54 |
| ▸ | TEK | Q02763 | 11/20 | 0.45 |
| ▸ | KDR | P35968 | 7/20 | 0.38 |
| ▸ | LCK | P06239 | 5/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL581733 | 0.94 | AURKB (0.51) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL580771 | 0.90 | TEK (0.46) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL580441 | 0.89 | TEK (0.45) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL580660 | 0.89 | AURKB (0.47) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL580648 | 0.88 | AURKB (0.44) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL580714 | 0.87 | TEK (0.45) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL15810173 | 0.87 | AURKB (0.45) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL580587 | 0.85 | TEK (0.44) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL580453 | 0.83 | TEK (0.47) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL581418 | 0.81 | AURKA (0.39) | AURKBAURKATPX2TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984353-B1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC (US) | 2015-12-30 | — | — | EP | disclosed |
| EP-2418209-B1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC (US) | 2014-06-25 | — | — | EP | disclosed |
| EP-2418209-A1 | Aurora kinase modulators and method of use | Amgen Inc. (US) | 2012-02-15 | — | — | EP | disclosed |