Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 14/20 | 0.64 |
| ▸ | AURKA | O14965 | 10/20 | 0.64 |
| ▸ | TPX2 | Q9ULW0 | 8/20 | 0.64 |
| ▸ | TEK | Q02763 | 6/20 | 0.51 |
| ▸ | ULK1 | O75385 | 1/20 | 0.44 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.44 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | FES | P07332 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | BCR | P11274 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.44 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.44 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | CLK3 | P49761 | 1/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15810171 | 0.87 | AURKB (0.67) | AURKBAURKATPX2TEKULK1 | |
| SCHEMBL15810152 | 0.86 | AURKB (0.83) | AURKBAURKATPX2TEKULK1 | |
| SCHEMBL587082 | 0.83 | AURKB (0.68) | AURKBAURKATPX2TEKULK1 | |
| SCHEMBL580938 | 0.79 | AURKB (0.77) | AURKBAURKATPX2TEKULK1 | |
| SCHEMBL581732 | 0.79 | AURKB (0.77) | AURKBAURKATPX2TEKULK1 | |
| SCHEMBL580531 | 0.79 | AURKB (0.87) | AURKBAURKATPX2TEKULK1 | |
| SCHEMBL580775 | 0.78 | AURKB (0.84) | AURKBAURKATPX2TEKULK1 | |
| SCHEMBL581323 | 0.78 | AURKB (1.00) | AURKBAURKATPX2TEKULK1 | |
| SCHEMBL580992 | 0.78 | AURKB (0.63) | AURKBAURKATPX2TEKULK1 | |
| SCHEMBL580434 | 0.78 | AURKB (0.63) | AURKBAURKATPX2TEKULK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2418209-A1 | Aurora kinase modulators and method of use | Amgen Inc. (US) | 2012-02-15 | — | — | EP | disclosed |