Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.72 |
| ▸ | MAPT | P10636 | 12/20 | 0.72 |
| ▸ | NPC1 | O15118 | 7/20 | 0.72 |
| ▸ | RAB9A | P51151 | 7/20 | 0.72 |
| ▸ | HTT | P42858 | 7/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.72 |
| ▸ | MEN1 | O00255 | 5/20 | 0.72 |
| ▸ | CA12 | O43570 | 1/20 | 0.72 |
| ▸ | CA1 | P00915 | 1/20 | 0.72 |
| ▸ | CA2 | P00918 | 1/20 | 0.72 |
| ▸ | CA9 | Q16790 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.66 |
| ▸ | HPGD | P15428 | 4/20 | 0.66 |
| ▸ | GAA | P10253 | 3/20 | 0.66 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.64 |
| ▸ | LMNA | P02545 | 4/20 | 0.64 |
| ▸ | CASP3 | P42574 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL723372 | 1.00 | KDM4E (0.72) | KDM4EMAPTNPC1RAB9AHTT | |
| SCHEMBL29382751 | 1.00 | KDM4E (0.72) | KDM4EMAPTNPC1RAB9AHTT | |
| SCHEMBL5815393 | 1.00 | KDM4E (0.72) | KDM4EMAPTNPC1RAB9AHTT | |
| SCHEMBL12746378 | 0.87 | CA12 (0.77) | KDM4EMAPTNPC1RAB9AHTT | |
| SCHEMBL28520457 | 0.87 | MAPT (0.73) | KDM4EMAPTNPC1RAB9AHTT | |
| SCHEMBL14195185 | 0.87 | MAPT (0.73) | KDM4EMAPTNPC1RAB9AHTT | |
| SCHEMBL12746253 | 0.86 | CA12 (0.75) | KDM4EMAPTNPC1RAB9AHTT | |
| SCHEMBL10049642 | 0.86 | CA12 (0.75) | KDM4EMAPTNPC1RAB9AHTT | |
| SCHEMBL10049932 | 0.84 | MAPT (0.74) | KDM4EMAPTNPC1RAB9AHTT | |
| SCHEMBL10049962 | 0.82 | CA12 (0.66) | KDM4EMAPTNPC1RAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006136008-A1 | SALICYLIC ACID HYDRAZONES AS INHIBITORS OF THE ERK MAPKINASE PATHWAY AND FOR THE TREATMENT OF CANCER | UNIVERSITY HEALTH NETWORK (CA) | 2006-12-28 | — | — | WO | disclosed |