Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.57 |
| ▸ | HTR2B | P41595 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | GBA1 | P04062 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.49 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5811302 | 0.85 | MAPT (0.54) | HTR2CHTR2BMAPTNPC1SMN1; SMN2 | |
| SCHEMBL5816607 | 0.84 | MAPT (0.57) | HTR2CHTR2BMAPTNPC1SMN1; SMN2 | |
| SCHEMBL7095507 | 0.83 | HTR2C (0.72) | HTR2CHTR2BMAPTNPC1SMN1; SMN2 | |
| SCHEMBL5809567 | 0.83 | MAPT (0.48) | HTR2CHTR2BMAPTNPC1SMN1; SMN2 | |
| SCHEMBL5810995 | 0.83 | MAPT (0.48) | HTR2CHTR2BMAPTNPC1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5964523 | 0.82 | HTR2C (0.70) | HTR2CHTR2BMAPTNPC1SMN1; SMN2 | |
| SCHEMBL5817183 | 0.82 | PIK3R1 (0.55) | HTR2CHTR2BMAPTNPC1SMN1; SMN2 | |
| SCHEMBL5816874 | 0.81 | NPC1 (0.61) | MAPTNPC1SMN1; SMN2RAB9AMEN1 | |
| SCHEMBL5814866 | 0.81 | MAPT (0.46) | HTR2CHTR2BMAPTNPC1SMN1; SMN2 | |
| SCHEMBL5812162 | 0.78 | MEN1 (0.48) | HTR2CHTR2BMAPTNPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6596730-B1 | Phenyl urea and phenyl thiourea derivatives | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-07-22 | — | — | US | claimed |
| US-20060178307-A1 | Modulation of NMDA receptor currents via orexin receptor and/or CRF receptor | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2006-08-10 | — | — | US | disclosed |
| WO-2006081522-A2 | MODULATION OF NMDA RECEPTOR CURRENTS VIA OREXIN RECEPTOR AND/OR CRF RECEPTOR | THE REGENTS OF THE UNVERSITY OF CALIFORNIA (US) | 2006-08-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060178307-A1 | Modulation of NMDA receptor currents via orexin receptor and/or CRF receptor | HCRTR2, HCRTR1, GRIN2B | HTR2C 172/4885HTR2B 84/4885MAPT 2643/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.