Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.35 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.35 |
| ▸ | CHRNG | P07510 | 1/20 | 0.35 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.35 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | CHRND | Q07001 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL582147 | 0.99 | SLC6A2 (0.35) | SLC6A2SLC6A4SLC6A3CHRNA1CHRNG | |
| Hydrochloric Acid SCHEMBL580625 | 0.86 | SLC6A2 (0.37) | SLC6A2SLC6A4SLC6A3CHRNA1CHRNG | |
| SCHEMBL582145 | 0.85 | SLC6A2 (0.37) | SLC6A2SLC6A4SLC6A3CHRNA1CHRNG | |
| SCHEMBL3063445 | 0.84 | KDM1A (0.42) | SLC6A2SLC6A4SLC6A3CHRNA1CHRNG | |
| Hydrochloric Acid SCHEMBL581998 | 0.84 | MAPT (0.32) | MAPTTDP1 | |
| Hydrochloric Acid SCHEMBL580883 | 0.84 | SLC6A2 (0.36) | SLC6A2SLC6A4SLC6A3CHRNA1CHRNG | |
| Hydrochloric Acid SCHEMBL580941 | 0.83 | KDM1A (0.41) | SLC6A2SLC6A4SLC6A3CHRNA1CHRNG | |
| SCHEMBL581068 | 0.81 | TDP1 (0.44) | SLC6A2MAPTTDP1 | |
| Hydrochloric Acid SCHEMBL581553 | 0.81 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3CHRNA1CHRNG | |
| SCHEMBL4505964 | 0.81 | TDP1 (0.44) | SLC6A2MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417131-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010117323-A1 | METHOD AND APPARATUS FOR PRODUCING HEAT ENERGY AND CARBON DIOXIDE | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | WO | disclosed |