Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 4/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.48 |
| ▸ | TPX2 | Q9ULW0 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PDE1A | P54750 | 1/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL581902 | 0.90 | AURKA (0.60) | AURKAAURKBTPX2PDE10AULK1 | |
| SCHEMBL581142 | 0.88 | AURKA (0.59) | AURKAAURKBTPX2PDE10AULK1 | |
| SCHEMBL581147 | 0.86 | AURKA (0.43) | AURKAAURKBTPX2PDE10AULK1 | |
| SCHEMBL581228 | 0.84 | AURKA (0.46) | AURKAAURKBTPX2PDE10AULK1 | |
| SCHEMBL581018 | 0.84 | AURKA (0.58) | AURKAAURKBTPX2PDE10AULK1 | |
| SCHEMBL581414 | 0.81 | AURKA (0.62) | AURKAAURKBTPX2PDE10AULK1 | |
| SCHEMBL580426 | 0.81 | AURKA (0.71) | AURKAAURKBTPX2PDE10AULK1 | |
| SCHEMBL581213 | 0.80 | AURKA (0.51) | AURKAAURKBTPX2KDM4EPDE5A | |
| SCHEMBL580472 | 0.80 | AURKA (0.59) | AURKAAURKBTPX2PDE10AULK1 | |
| SCHEMBL581155 | 0.79 | AURKA (0.42) | AURKAAURKBTPX2PDE10AKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984353-B1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC (US) | 2015-12-30 | — | — | EP | disclosed |
| EP-2418209-B1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC (US) | 2014-06-25 | — | — | EP | disclosed |
| EP-2418209-A1 | Aurora kinase modulators and method of use | Amgen Inc. (US) | 2012-02-15 | — | — | EP | disclosed |