Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK11 | Q15759 | 13/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 13/20 | 0.57 |
| ▸ | MAPK13 | O15264 | 8/20 | 0.57 |
| ▸ | MAPK12 | P53778 | 7/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5812295 | 0.87 | MAPK13 (0.53) | MAPK11MAPK14MAPK13MAPK12CYP2C9 | |
| SCHEMBL5807295 | 0.82 | MAPK11 (0.44) | MAPK11MAPK14MAPK13MAPK12CYP2C9 | |
| SCHEMBL5808593 | 0.82 | MAPK11 (0.44) | MAPK11MAPK14MAPK13MAPK12CYP2C9 | |
| SCHEMBL4243757 | 0.82 | MAPK11 (0.51) | MAPK11MAPK14MAPK13MAPK12CYP2C9 | |
| SCHEMBL4245632 | 0.82 | MAPK11 (0.51) | MAPK11MAPK14MAPK13MAPK12CYP2C9 | |
| SCHEMBL5806925 | 0.82 | MAPK11 (0.51) | MAPK11MAPK14MAPK13MAPK12CYP2C9 | |
| SCHEMBL4241190 | 0.79 | MAPK11 (0.49) | MAPK11MAPK14MAPK13MAPK12CYP2C9 | |
| SCHEMBL4243488 | 0.79 | MAPK11 (0.50) | MAPK11MAPK14MAPK13MAPK12CYP2C9 | |
| SCHEMBL4239796 | 0.79 | MAPK11 (0.46) | MAPK11MAPK14MAPK13MAPK12CYP2C9 | |
| SCHEMBL4239955 | 0.78 | MAPK11 (0.51) | MAPK11MAPK14MAPK13MAPK12CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006038734-A1 | PYRIDAZINONE DERIVATIVES CYTOKINES INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2006-04-13 | — | — | WO | disclosed |