Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 9/20 | 0.41 |
| ▸ | MAP2K4 | P45985 | 7/20 | 0.41 |
| ▸ | MAPK6 | Q16659 | 4/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.40 |
| ▸ | MAPKAPK3 | Q16644 | 3/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5375056 | 0.87 | MAP2K4 (0.39) | MAPK1MAP2K4MAPK6MAPK8MAPKAPK3 | |
| SCHEMBL5378102 | 0.85 | MAP2K4 (0.41) | MAPK1MAP2K4MAPK6MAPK8MAPKAPK3 | |
| SCHEMBL5377641 | 0.82 | NTRK1 (0.43) | MAPK1MAP2K4MAPK8NTRK1CSNK1D | |
| SCHEMBL5372830 | 0.80 | NTRK1 (0.44) | MAPK1MAP2K4MAPK8NTRK1CSNK1D | |
| SCHEMBL5379444 | 0.78 | MAPK1 (0.42) | MAPK1MAP2K4MAPK6MAPK8MAPKAPK3 | |
| SCHEMBL5382869 | 0.78 | EGFR (0.45) | CSNK1DMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5380035 | 0.77 | NTRK1 (0.47) | MAPK1MAP2K4NTRK1CSNK1D | |
| SCHEMBL5377517 | 0.74 | NTRK1 (0.42) | MAPK1MAP2K4NTRK1CSNK1DTTK | |
| SCHEMBL5376638 | 0.74 | LRRK2 (0.44) | MAPK1MAP2K4MAPK6MAPKAPK3NTRK1 | |
| SCHEMBL5373018 | 0.74 | NAMPT (0.40) | MAPK1NTRK1CSNK1DMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1618093-A2 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | Signal Pharmaceuticals LLC (US) | 2006-01-25 | — | — | EP | disclosed |
| WO-2004094388-A2 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-11-04 | — | — | WO | disclosed |