Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 4/20 | 0.71 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.71 |
| ▸ | TPX2 | Q9ULW0 | 2/20 | 0.71 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.55 |
| ▸ | ULK1 | O75385 | 1/20 | 0.53 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.53 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | FES | P07332 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | BCR | P11274 | 1/20 | 0.53 |
| ▸ | BRAF | P15056 | 1/20 | 0.53 |
| ▸ | NQO2 | P16083 | 1/20 | 0.53 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.53 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.53 |
| ▸ | CLK1 | P49759 | 1/20 | 0.53 |
| ▸ | CLK2 | P49760 | 1/20 | 0.53 |
| ▸ | CLK3 | P49761 | 1/20 | 0.53 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL580403 | 0.93 | AURKA (0.73) | AURKAAURKBTPX2PDE10AULK1 | |
| SCHEMBL581574 | 0.93 | AURKA (0.62) | AURKAAURKBTPX2PDE10AULK1 | |
| SCHEMBL581514 | 0.89 | AURKA (0.58) | AURKAAURKBTPX2PDE10AULK1 | |
| SCHEMBL581165 | 0.89 | AURKA (0.69) | AURKAAURKBTPX2PDE10AULK1 | |
| SCHEMBL580841 | 0.86 | AURKA (0.59) | AURKAAURKBTPX2PDE10AULK1 | |
| SCHEMBL580405 | 0.85 | AURKA (0.77) | AURKAAURKBTPX2PDE10AULK1 | |
| SCHEMBL580541 | 0.85 | AURKA (0.77) | AURKAAURKBTPX2PDE10AULK1 | |
| SCHEMBL581019 | 0.84 | AURKA (0.58) | AURKAAURKBTPX2ULK1RPS6KA5 | |
| SCHEMBL580671 | 0.83 | AURKA (0.77) | AURKAAURKBTPX2PDE10AULK1 | |
| SCHEMBL581448 | 0.83 | AURKB (0.84) | AURKAAURKBTPX2PDE10AULK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984353-B1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC (US) | 2015-12-30 | — | — | EP | disclosed |
| EP-2418209-B1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC (US) | 2014-06-25 | — | — | EP | disclosed |
| EP-2418209-A1 | Aurora kinase modulators and method of use | Amgen Inc. (US) | 2012-02-15 | — | — | EP | disclosed |