Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 18/20 | 0.51 |
| ▸ | SRC | P12931 | 16/20 | 0.51 |
| ▸ | TEK | Q02763 | 16/20 | 0.51 |
| ▸ | KDR | P35968 | 3/20 | 0.50 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.48 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.48 |
| ▸ | FYN | P06241 | 3/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | LYN | P07948 | 1/20 | 0.41 |
| ▸ | HCK | P08631 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5813018 | 0.88 | LCK (0.64) | LCKSRCTEKKDRLIMK1 | |
| SCHEMBL6665059 | 0.82 | LCK (0.60) | LCKSRCTEKKDRLIMK1 | |
| SCHEMBL6435593 | 0.79 | LCK (0.71) | LCKSRCTEKKDRLIMK1 | |
| SCHEMBL6430357 | 0.79 | LCK (0.71) | LCKSRCTEKKDRLIMK1 | |
| SCHEMBL6430361 | 0.79 | LCK (0.71) | LCKSRCTEKKDRLIMK1 | |
| SCHEMBL6430412 | 0.78 | SRC (0.58) | LCKSRCTEKKDRLIMK1 | |
| SCHEMBL6430413 | 0.78 | SRC (0.58) | LCKSRCTEKKDRLIMK1 | |
| SCHEMBL7152942 | 0.77 | SRC (0.60) | LCKSRCTEKKDRLIMK1 | |
| SCHEMBL4824923 | 0.77 | LCK (0.80) | LCKSRCTEKKDRLIMK1 | |
| SCHEMBL4824918 | 0.77 | LCK (0.80) | LCKSRCTEKKDRLIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385524-A4 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2006-02-01 | — | — | EP | disclosed |
| EP-1385524-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | Abbott GmbH & Co. KG (DE) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002080926-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO. KG (DE) | 2002-10-17 | — | — | WO | disclosed |