Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | CCND3 | P30281 | 1/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.39 |
| ▸ | CDK1 | P06493 | 2/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5812981 | 1.00 | BRAF (0.50) | BRAFKCNH2MAPK10FYNRIPK2 | |
| SCHEMBL5816373 | 0.97 | BRAF (0.53) | BRAFKCNH2MAPK10FYNRIPK2 | |
| SCHEMBL5815392 | 0.93 | BRAF (0.49) | BRAFKCNH2FYNRIPK2CDK4 | |
| SCHEMBL5819038 | 0.93 | BRAF (0.49) | BRAFKCNH2MAPK10FYNRIPK2 | |
| SCHEMBL5814577 | 0.92 | BRAF (0.50) | BRAFKCNH2RIPK2CDK4CCND1 | |
| SCHEMBL5812160 | 0.92 | KCNH2 (0.55) | BRAFKCNH2RIPK2CDK4CCND1 | |
| SCHEMBL5818887 | 0.92 | BRAF (0.50) | BRAFKCNH2MAPK10FYNRIPK2 | |
| SCHEMBL5819465 | 0.89 | MAPK14 (0.51) | BRAFKCNH2MAPK10RIPK2CDK4 | |
| SCHEMBL5813731 | 0.89 | ADORA1 (0.49) | BRAFKCNH2MAPK10CDK4CCND1 | |
| SCHEMBL5819447 | 0.89 | ADORA1 (0.49) | BRAFKCNH2MAPK10CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006137658-A1 | NEW SUBSTITUTED 1,3-THIAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF HAVING IMMUNOSUPPRESSION AND INFLAMMATION INHIBITORY ACITIVITY, INTERMEDIATE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, A PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DONGBU HITEK CO., LTD. (KR) | 2006-12-28 | — | — | WO | claimed |