Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | CDK4 | P11802 | 2/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CCND3 | P30281 | 1/20 | 0.43 |
| ▸ | CDK7 | P50613 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | CCNH | P51946 | 1/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5814835 | 0.92 | MAPK14 (0.48) | MAPK14IKBKBBRAFCDK2CDK4 | |
| SCHEMBL5815238 | 0.91 | MAPK14 (0.45) | MAPK14IKBKBBRAFCDK2CDK4 | |
| SCHEMBL5818597 | 0.90 | BRAF (0.53) | IKBKBBRAFHRH4CDK2CCNA2 | |
| SCHEMBL5814087 | 0.90 | KCNH2 (0.49) | MAPK14IKBKBBRAFCDK2CDK4 | |
| SCHEMBL5819465 | 0.89 | MAPK14 (0.51) | MAPK14BRAFHRH4CDK2CDK4 | |
| SCHEMBL5818908 | 0.88 | MAPK14 (0.49) | MAPK14IKBKBBRAFHRH4CDK2 | |
| SCHEMBL5817861 | 0.88 | MAPK14 (0.50) | MAPK14BRAFHRH4CDK2CDK4 | |
| SCHEMBL5814577 | 0.87 | BRAF (0.50) | IKBKBBRAFHRH4CDK2CDK4 | |
| SCHEMBL5817136 | 0.87 | KCNH2 (0.49) | MAPK14IKBKBBRAFCDK2CDK4 | |
| SCHEMBL5815400 | 0.87 | MAPK14 (0.49) | MAPK14BRAFHRH4CDK2CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006137658-A1 | NEW SUBSTITUTED 1,3-THIAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF HAVING IMMUNOSUPPRESSION AND INFLAMMATION INHIBITORY ACITIVITY, INTERMEDIATE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, A PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DONGBU HITEK CO., LTD. (KR) | 2006-12-28 | — | — | WO | claimed |