Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | CDK4 | P11802 | 7/20 | 0.43 |
| ▸ | CCND1 | P24385 | 5/20 | 0.43 |
| ▸ | CCND3 | P30281 | 2/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 7/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 7/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.43 |
| ▸ | GSK3B | P49841 | 3/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | INSR | P06213 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5812777 | 1.00 | KCNH2 (0.45) | KCNH2CDK4CCND1CCND3CDK6 | |
| SCHEMBL5813694 | 0.97 | KCNH2 (0.45) | KCNH2CDK4CCND1CCND3CDK6 | |
| SCHEMBL5818778 | 0.93 | HRH4 (0.50) | KCNH2CDK4CCND1CCND3CDK6 | |
| SCHEMBL5814648 | 0.93 | KCNH2 (0.50) | KCNH2CDK4CCND1CCND3CDK6 | |
| SCHEMBL5818639 | 0.93 | CDK1 (0.42) | KCNH2CDK4CCND1CCND3CDK6 | |
| SCHEMBL5817256 | 0.92 | HRH4 (0.51) | KCNH2CDK4CCND1CCND3CDK6 | |
| SCHEMBL5813653 | 0.92 | KCNH2 (0.51) | KCNH2CDK4CCND1CCND3CDK6 | |
| SCHEMBL5813579 | 0.92 | HRH4 (0.42) | KCNH2CDK4CCND1CCND3CDK6 | |
| SCHEMBL5812995 | 0.88 | KCNH2 (0.39) | KCNH2CDK4MAPK10CDK1CCNB1 | |
| SCHEMBL5818808 | 0.88 | KCNH2 (0.50) | KCNH2CDK4CCND1CCND3CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006137658-A1 | NEW SUBSTITUTED 1,3-THIAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF HAVING IMMUNOSUPPRESSION AND INFLAMMATION INHIBITORY ACITIVITY, INTERMEDIATE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, A PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DONGBU HITEK CO., LTD. (KR) | 2006-12-28 | — | — | WO | disclosed |