Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 18/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2909818 | 0.84 | SLC6A2 (0.67) | SLC6A2SLC6A4CYP2D6KCNH2SLC6A3 | |
| Hydrochloric Acid SCHEMBL2904813 | 0.83 | SLC6A2 (0.66) | SLC6A2SLC6A4CYP2D6KCNH2SLC6A3 | |
| SCHEMBL5815870 | 0.82 | SLC6A2 (0.52) | SLC6A2SLC6A4CYP2D6KCNH2SLC6A3 | |
| SCHEMBL2908837 | 0.80 | SLC6A2 (0.55) | SLC6A2SLC6A4CYP2D6KCNH2 | |
| SCHEMBL2904533 | 0.80 | SLC6A2 (0.70) | SLC6A2SLC6A4CYP2D6KCNH2SLC6A3 | |
| Hydrochloric Acid SCHEMBL2905560 | 0.79 | SLC6A2 (0.69) | SLC6A2SLC6A4CYP2D6KCNH2SLC6A3 | |
| SCHEMBL5762714 | 0.78 | DRD4 (0.44) | CYP2D6KCNH2 | |
| SCHEMBL2908757 | 0.78 | SLC6A2 (0.67) | SLC6A2SLC6A4CYP2D6SLC6A3 | |
| Hydrochloric Acid SCHEMBL2907221 | 0.77 | SLC6A2 (0.66) | SLC6A2SLC6A4CYP2D6SLC6A3 | |
| SCHEMBL2907460 | 0.75 | SLC6A2 (0.69) | SLC6A2SLC6A4CYP2D6SLC6A3HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682523-A1 | MORPHOLINE DERIVATIVES AS NOREPINEPHRINE REUPTAKE INHIBITORS | ELI LILLY AND COMPANY (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005047272-A1 | MORPHOLINE DERIVATIVES AS NOREPINEPHRINE REUPTAKE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-05-26 | — | — | WO | disclosed |