Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 9/20 | 0.61 |
| ▸ | FGFR2 | P21802 | 8/20 | 0.61 |
| ▸ | FGFR3 | P22607 | 8/20 | 0.61 |
| ▸ | KDR | P35968 | 7/20 | 0.61 |
| ▸ | KIT | P10721 | 2/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 7/20 | 0.38 |
| ▸ | JAK1 | P23458 | 6/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5815284 | 0.91 | FGFR1 (0.64) | FGFR1FGFR2FGFR3KDRKIT | |
| SCHEMBL5813135 | 0.90 | FGFR1 (0.62) | FGFR1FGFR2FGFR3KDRKIT | |
| SCHEMBL5819717 | 0.89 | FGFR1 (0.61) | FGFR1FGFR2FGFR3KDRKIT | |
| SCHEMBL5823306 | 0.89 | FGFR1 (0.61) | FGFR1FGFR2FGFR3KDRKIT | |
| SCHEMBL5816629 | 0.89 | FGFR1 (0.59) | FGFR1FGFR2FGFR3KDRKIT | |
| SCHEMBL5814988 | 0.89 | FGFR1 (0.76) | FGFR1FGFR2FGFR3KDRKIT | |
| SCHEMBL5817863 | 0.88 | FGFR1 (0.61) | FGFR1FGFR2FGFR3KDRKIT | |
| SCHEMBL5819689 | 0.88 | FGFR1 (0.61) | FGFR1FGFR2FGFR3KDRKIT | |
| SCHEMBL5815355 | 0.86 | FGFR1 (0.58) | FGFR1FGFR2FGFR3KDRKIT | |
| SCHEMBL5817302 | 0.86 | FGFR1 (0.58) | FGFR1FGFR2FGFR3KDRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006124731-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-11-23 | — | — | WO | claimed |
| WO-2006124731-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-11-23 | — | — | WO | disclosed |