Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 12/20 | 0.64 |
| ▸ | SRC | P12931 | 6/20 | 0.64 |
| ▸ | TEK | Q02763 | 4/20 | 0.64 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | FYN | P06241 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | PAK4 | O96013 | 1/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
| ▸ | INSR | P06213 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | LYN | P07948 | 1/20 | 0.48 |
| ▸ | HCK | P08631 | 1/20 | 0.48 |
| ▸ | FGR | P09769 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5823957 | 0.91 | LCK (0.56) | LCKSRCTEKFYNPLK4 | |
| SCHEMBL6278846 | 0.91 | LCK (0.56) | LCKSRCTEKFYNTP53 | |
| SCHEMBL4821436 | 0.89 | LCK (0.80) | LCKSRCTEKFYNPLK4 | |
| SCHEMBL5823810 | 0.85 | SRC (0.49) | LCKSRCTEKFYNPLK4 | |
| SCHEMBL6218794 | 0.82 | LCK (0.69) | LCKSRCTEKFYNPLK4 | |
| SCHEMBL5823953 | 0.81 | LCK (0.69) | LCKSRCTEKFYNPLK4 | |
| SCHEMBL6278841 | 0.81 | LCK (0.69) | LCKSRCTEKFYNPLK4 | |
| SCHEMBL5804828 | 0.81 | LCK (0.68) | LCKSRCTEKFYNPLK4 | |
| Acetic Acid SCHEMBL4828254 | 0.80 | LCK (0.67) | LCKSRCTEKFYNPLK4 | |
| SCHEMBL7050233 | 0.80 | LCK (0.66) | LCKSRCTEKFYNPLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385524-A4 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2006-02-01 | — | — | EP | disclosed |
| EP-1385524-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | Abbott GmbH & Co. KG (DE) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002080926-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO. KG (DE) | 2002-10-17 | — | — | WO | disclosed |