Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.41 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | CDK1 | P06493 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | PLK4 | O00444 | 2/20 | 0.41 |
| ▸ | PIM1 | P11309 | 2/20 | 0.41 |
| ▸ | PRKACA | P17612 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.41 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5813597 | 0.99 | ADORA1 (0.46) | ADORA1IKBKBMAPK8MAPK9MAPK10 | |
| SCHEMBL5819084 | 0.96 | IKBKB (0.46) | ADORA1IKBKBMAPK8MAPK9MAPK10 | |
| SCHEMBL5814640 | 0.90 | BRAF (0.47) | IKBKBMAPK8MAPK9MAPK10KDR | |
| SCHEMBL5817822 | 0.90 | MAPK14 (0.46) | IKBKBMAPK8MAPK9MAPK10KDR | |
| SCHEMBL5813948 | 0.89 | MAPK14 (0.46) | IKBKBMAPK8MAPK9MAPK10KDR | |
| SCHEMBL5814974 | 0.89 | BRAF (0.47) | IKBKBMAPK8MAPK9KDREGFR | |
| SCHEMBL5818423 | 0.89 | MAPK9 (0.46) | ADORA1IKBKBMAPK8MAPK9MAPK10 | |
| SCHEMBL5819550 | 0.88 | MAPK9 (0.47) | MAPK8MAPK9KDRCDK1CDK2 | |
| SCHEMBL5812484 | 0.88 | MAPK9 (0.47) | ADORA1IKBKBMAPK8MAPK9MAPK10 | |
| SCHEMBL5819553 | 0.87 | MAPK9 (0.48) | MAPK9CDK1PIM1CDK2MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006137658-A1 | NEW SUBSTITUTED 1,3-THIAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF HAVING IMMUNOSUPPRESSION AND INFLAMMATION INHIBITORY ACITIVITY, INTERMEDIATE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, A PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DONGBU HITEK CO., LTD. (KR) | 2006-12-28 | — | — | WO | claimed |