Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 10/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21332671 | 0.88 | HDAC3 (0.47) | PTGER1GAARAB9AKMT2AMEN1 | |
| SCHEMBL4092138 | 0.83 | PTGER1 (0.75) | PTGER1 | |
| SCHEMBL22054628 | 0.81 | GAA (0.59) | PTGER1CYP1A2GAARAB9AAURKA | |
| SCHEMBL6078431 | 0.81 | AURKA (0.48) | GAARAB9AAURKARPS6KB1KMT2A | |
| SCHEMBL1137143 | 0.81 | PTGER1 (0.59) | PTGER1CYP1A2AURKARPS6KB1KMT2A | |
| SCHEMBL5813326 | 0.81 | SMYD3 (0.51) | GAARAB9AKMT2AMEN1POLB | |
| SCHEMBL9133656 | 0.80 | PTGER1 (0.44) | PTGER1CYP1A2AURKARPS6KB1USP30 | |
| SCHEMBL17324801 | 0.79 | AURKA (0.52) | PTGER1CYP1A2GAAAURKARPS6KB1 | |
| SCHEMBL1232379 | 0.78 | PTGER1 (0.64) | PTGER1CYP1A2GAAAURKARPS6KB1 | |
| SCHEMBL1233306 | 0.77 | SMN1; SMN2 (0.60) | PTGER1CYP1A2GAAAURKARPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006133885-A1 | TRICYCLIC FUSED INDOLE DERIVATIVES AND THEIR USE AS AURORA KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-12-21 | — | — | WO | disclosed |