Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK6 | Q16659 | 10/20 | 0.63 |
| ▸ | GSK3A | P49840 | 4/20 | 0.50 |
| ▸ | GSK3B | P49841 | 4/20 | 0.50 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 3/20 | 0.39 |
| ▸ | CD38 | P28907 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5820134 | 0.89 | MAPK6 (0.53) | MAPK6GSK3AGSK3BAURKAMAPK8 | |
| SCHEMBL16011964 | 0.88 | MAPK6 (0.69) | MAPK6GSK3AGSK3BAURKASYK | |
| SCHEMBL5814193 | 0.88 | MAPK6 (0.51) | MAPK6GSK3AGSK3BAURKAMAPK8 | |
| SCHEMBL16014927 | 0.88 | MAPK6 (0.82) | MAPK6GSK3AGSK3BAURKAMAPK8 | |
| SCHEMBL16014924 | 0.88 | MAPK6 (0.82) | MAPK6GSK3AGSK3BAURKAMAPK8 | |
| SCHEMBL18830121 | 0.88 | MAPK6 (0.82) | MAPK6GSK3AGSK3BAURKAMAPK8 | |
| SCHEMBL17435258 | 0.88 | MAPK6 (0.82) | MAPK6GSK3AGSK3BAURKAMAPK8 | |
| SCHEMBL5818515 | 0.87 | MAPK6 (0.67) | MAPK6GSK3AGSK3BAURKASYK | |
| SCHEMBL5820028 | 0.84 | MAPK6 (0.53) | MAPK6GSK3AGSK3BAURKAMAPK8 | |
| SCHEMBL16012192 | 0.83 | MAPK6 (0.75) | MAPK6GSK3AGSK3BAURKASYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006091737-A1 | MODULATORS OF GSK-3 ACTIVITY | KEMIA, INC. (US) | 2006-08-31 | — | — | WO | disclosed |