Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11175542 | 0.85 | MEN1 (0.57) | SMN1; SMN2MAPK1TSHRCYP2C9CYP2C19 | |
| SCHEMBL11181485 | 0.85 | MEN1 (0.57) | SMN1; SMN2MAPK1TSHRCYP2C9CYP2C19 | |
| SCHEMBL31565676 | 0.84 | TSHR (0.62) | SMN1; SMN2MAPK1TSHRCYP2C9CYP2C19 | |
| SCHEMBL15848161 | 0.83 | TSHR (0.66) | SMN1; SMN2MAPK1TSHRCYP2C9CYP2C19 | |
| SCHEMBL28853128 | 0.78 | TSHR (0.54) | SMN1; SMN2MAPK1TSHRCYP2C9CYP2C19 | |
| SCHEMBL28185881 | 0.75 | TSHR (0.50) | SMN1; SMN2MAPK1TSHRCYP2C9CYP2C19 | |
| SCHEMBL6318647 | 0.74 | TSHR (0.47) | SMN1; SMN2MAPK1TSHRCYP2C9CYP2C19 | |
| SCHEMBL31680925 | 0.73 | KMT2A (0.56) | SMN1; SMN2TSHRCYP2C9CYP2C19CYP3A4 | |
| SCHEMBL5069997 | 0.73 | TSHR (0.65) | SMN1; SMN2TSHRCYP2C9CYP2C19CYP3A4 | |
| SCHEMBL17478912 | 0.73 | KDM4E (0.46) | SMN1; SMN2KMT2AALDH1A1LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006044645-A2 | SULFAMOYL BENZAMIDES AND METHODS OF THEIR USE | ADOLOR CORPORATION (US) | 2006-04-27 | — | — | WO | claimed |