Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 8/20 | 0.57 |
| ▸ | FGFR3 | P22607 | 8/20 | 0.57 |
| ▸ | KDR | P35968 | 8/20 | 0.57 |
| ▸ | FGFR2 | P21802 | 7/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.55 |
| ▸ | KIT | P10721 | 3/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.55 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LCK | P06239 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5814256 | 0.85 | FGFR1 (0.62) | FGFR1FGFR3KDRFGFR2PDGFRB | |
| SCHEMBL5814252 | 0.82 | FGFR1 (0.58) | FGFR1FGFR3KDRFGFR2PDGFRB | |
| SCHEMBL19922636 | 0.75 | TNK2 (0.42) | FGFR1FGFR3KDRPDGFRBKIT | |
| SCHEMBL15583173 | 0.73 | FGFR1 (1.00) | FGFR1FGFR3KDRFGFR2PDGFRB | |
| SCHEMBL5813589 | 0.73 | TNK2 (0.61) | FGFR1FGFR3KDRFGFR2PDGFRB | |
| SCHEMBL3139215 | 0.72 | LCK (0.41) | FGFR1FGFR3KDRPDGFRBKIT | |
| SCHEMBL15555862 | 0.71 | FGFR1 (1.00) | FGFR1FGFR3KDRFGFR2PDGFRB | |
| SCHEMBL15556309 | 0.71 | FGFR1 (1.00) | FGFR1FGFR3KDRFGFR2PDGFRB | |
| SCHEMBL15583164 | 0.71 | FGFR1 (1.00) | FGFR1FGFR3KDRFGFR2PDGFRB | |
| SCHEMBL15556704 | 0.71 | FGFR1 (1.00) | FGFR1FGFR3KDRFGFR2PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006124731-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-11-23 | — | — | WO | disclosed |