Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 13/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL581781 | 1.00 | PLG (0.48) | PLGGABRA1GABRG2GABRB3ALDH1A1 | |
| SCHEMBL583154 | 0.92 | PLG (0.48) | PLGGABRA1GABRG2GABRB3CCNT1 | |
| SCHEMBL582115 | 0.92 | PLG (0.48) | PLGGABRA1GABRG2GABRB3CCNT1 | |
| SCHEMBL581744 | 0.85 | PLG (0.46) | PLGGABRA1GABRG2GABRB3ALDH1A1 | |
| SCHEMBL27965529 | 0.85 | PLG (0.46) | PLGGABRA1GABRG2GABRB3ALDH1A1 | |
| SCHEMBL28812553 | 0.85 | PLG (0.46) | PLGGABRA1GABRG2GABRB3ALDH1A1 | |
| SCHEMBL3075971 | 0.84 | PLG (0.43) | PLGALDH1A1TDP1ATMKCNH2 | |
| SCHEMBL586721 | 0.84 | PLG (0.43) | PLGALDH1A1TDP1ATMKCNH2 | |
| SCHEMBL582146 | 0.84 | PLG (0.43) | PLGALDH1A1TDP1ATMKCNH2 | |
| SCHEMBL587396 | 0.84 | PLG (0.43) | PLGALDH1A1TDP1ATMKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417131-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010117323-A1 | METHOD AND APPARATUS FOR PRODUCING HEAT ENERGY AND CARBON DIOXIDE | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | WO | disclosed |