Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 18/20 | 0.69 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.62 |
| ▸ | NCOR1 | O75376 | 2/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.62 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3553447 | 0.82 | HDAC1 (1.00) | HDAC1HDAC2HDAC3NCOR1CYP3A4 | |
| SCHEMBL211124 | 0.81 | HDAC1 (1.00) | HDAC1HDAC2HDAC3NCOR1CYP3A4 | |
| SCHEMBL8279054 | 0.81 | HDAC1 (0.79) | HDAC1HDAC2HDAC3NCOR1CYP3A4 | |
| SCHEMBL212106 | 0.80 | HDAC1 (0.80) | HDAC1HDAC2HDAC3NCOR1CYP3A4 | |
| SCHEMBL2733969 | 0.80 | HDAC1 (0.82) | HDAC1HDAC2HDAC3NCOR1CYP3A4 | |
| SCHEMBL210152 | 0.80 | HDAC1 (0.76) | HDAC1HDAC2HDAC3NCOR1CYP3A4 | |
| SCHEMBL2732829 | 0.79 | HDAC1 (0.85) | HDAC1HDAC2HDAC3NCOR1CYP3A4 | |
| SCHEMBL2733590 | 0.79 | HDAC1 (0.88) | HDAC1HDAC2HDAC3NCOR1CYP3A4 | |
| SCHEMBL213866 | 0.79 | HDAC1 (1.00) | HDAC1HDAC2HDAC3NCOR1CYP3A4 | |
| SCHEMBL1064494 | 0.78 | HDAC1 (1.00) | HDAC1HDAC2HDAC3NCOR1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1735319-A1 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2006-12-27 | — | — | EP | disclosed |
| WO-2005092899-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2005-10-06 | — | — | WO | disclosed |