SCHEMBL5819463

SCHEMBL5819463

CN(C)C(=O)c1cc(CNc2ccsc2C(=O)Nc2ccc3c(c2)OC(F)(F)O3)ccn1

nearest known ligand 0.83

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KIT P10721 20/20 0.83
BRAF P15056 20/20 0.83

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5821055 0.91 KIT (1.00) KITBRAF
SCHEMBL5790091 0.90 KIT (0.83) KITBRAF
SCHEMBL5808481 0.90 KIT (0.82) KITBRAF
SCHEMBL5808899 0.87 KIT (0.81) KITBRAF
SCHEMBL633953 0.86 KIT (0.92) KITBRAF
SCHEMBL4945370 0.86 KIT (0.81) KITBRAF
SCHEMBL5807439 0.86 KIT (0.80) KITBRAF
SCHEMBL5793670 0.86 KIT (0.77) KITBRAF
SCHEMBL5804716 0.86 KIT (0.77) KITBRAF
SCHEMBL5819532 0.86 KIT (0.79) KITBRAF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006023707-A2 2-AMINOTHIOPHENECARBOXAMIDES USEFUL AS CANCER CHEMOTHERAPEUTIC AGENTS BAYER PHARMACEUTICALS CORPORATION (US) 2006-03-02 WO disclosed