Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K2 | Q12851 | 8/20 | 0.62 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.62 |
| ▸ | MAP3K7 | O43318 | 6/20 | 0.62 |
| ▸ | MAP3K20 | Q9NYL2 | 6/20 | 0.62 |
| ▸ | CSK | P41240 | 4/20 | 0.62 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.62 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.62 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.61 |
| ▸ | ABL1 | P00519 | 5/20 | 0.61 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.61 |
| ▸ | RAF1 | P04049 | 2/20 | 0.61 |
| ▸ | LYN | P07948 | 2/20 | 0.61 |
| ▸ | SRC | P12931 | 2/20 | 0.61 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.61 |
| ▸ | ABL2 | P42684 | 2/20 | 0.61 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.61 |
| ▸ | FES | P07332 | 1/20 | 0.60 |
| ▸ | FER | P16591 | 1/20 | 0.60 |
| ▸ | FLT3 | P36888 | 1/20 | 0.60 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5819810 | 0.94 | MAP4K2 (0.60) | MAP4K2MAPK14MAP3K7MAP3K20CSK | |
| SCHEMBL5818216 | 0.90 | MAP4K2 (0.51) | MAP4K2MAPK14MAP3K7MAP3K20CSK | |
| SCHEMBL5820634 | 0.88 | MAP4K2 (0.55) | MAP4K2MAPK14MAP3K7MAP3K20CSK | |
| SCHEMBL5815047 | 0.85 | MAP4K2 (0.61) | MAP4K2MAP3K7TNK2ABL1RAF1 | |
| SCHEMBL3127005 | 0.84 | TNK2 (0.74) | MAP4K2TNK2ABL1SRCEPHB4 | |
| SCHEMBL5820613 | 0.83 | TNK2 (0.57) | MAP4K2TNK2ABL1RAF1SRC | |
| SCHEMBL3139682 | 0.83 | MAP4K2 (0.78) | MAP4K2MAPK14MAP3K7MAP3K20TNK2 | |
| SCHEMBL5813206 | 0.80 | MAPK14 (0.59) | MAP4K2MAPK14MAP3K7MAP3K20CSK | |
| SCHEMBL5813589 | 0.80 | TNK2 (0.61) | MAP4K2TNK2ABL1SRCEPHB4 | |
| SCHEMBL3132781 | 0.80 | TNK2 (0.80) | MAP4K2TNK2ABL1SRCEPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006124731-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-11-23 | — | — | WO | claimed |
| WO-2006124731-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-11-23 | — | — | WO | disclosed |